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. 2018 Jul 10;9:742. doi: 10.3389/fphar.2018.00742

FIGURE 10.

FIGURE 10

Interaction of RES with the metabolism of steroid hormones in MCF-7 breast cancer cells. RES inhibited the formation of the conjugated metabolites DHEA-S, E1-S, E2-S and E2-G, as well as the formation of E3, in a dose-dependent manner, thereby increasing the levels of AD, T, and active E2.