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Compared to control, monocrotaline (MCT)-induced RVfib are hyperproliferative as measured by Click-iT® EdU assay. Mitochondrial division inhibitor 1 (Mdivi-1; 25 μM) for 2 days and high dose of P110 (1 mM) for 3 days reduced proliferation in MCT-RVfib whereas lower doses of P110 had no effect. ∗P < 0.05 and ∗∗P < 0.01 versus PBS+DMSO or PBS+TAT group; $P < 0.05 and $$P < 0.01 versus the corresponding vehicle control group. n = 5 per group.
