FIGURE 3.

S1P release in washed platelets, in resting and stirring conditions. In resting conditions, S1P levels were not different between platelets from T2DM patients (d-PLT) and platelets from healthy subjects (h-PLT). +p < 0.05 vs. resting basal. In stirring samples, S1P levels were lower in d-PLT than in h-PLT both in the absence and in the presence of collagen. ^∗p < 0.001, ^∗∗p < 0.0001 vs. healthy-PLT (unpaired t-test); ^#p < 0.01, ^##p < 0.005 vs. corresponding stirring basal; ^§ p < 0.005, ^§§ p < 0.001 vs. corresponding resting conditions (Newman–Keuls multiple-range test).