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. 2018 Jul 10;9:875. doi: 10.3389/fphys.2018.00875

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Copyright © 2018 Russo, Femminò, Barale, Tullio, Geuna, Cavalot, Pagliaro and Penna.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Variation of the intra-platelet level of ROS measured by DCF fluorescence. (A) ROS level in resting platelets of diabetic patients (d-PLT) were higher than in resting platelets of healthy subjects (h-PLT). 20-min preincubation with apocynin (APO), diphenyleneiodonium (DPI), or indomethacin (INDO) reduced the levels of ROS produced by d-PLT. (B) PLT stimulation with arachidonic acid increased ROS levels in both h-PLTs and d-PLTs. ^∗∗∗p < 0.0001 vs. h-PLT; ^#p < 0.005, ^##p < 0.001 vs. resting d-PLT (paired t-test).