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. 2018 Jul 10;9:875. doi: 10.3389/fphys.2018.00875

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Copyright © 2018 Russo, Femminò, Barale, Tullio, Geuna, Cavalot, Pagliaro and Penna.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Protein content in platelets determined by Western blot. (A) Cyclooxygenase-1 (COX-1) levels were higher in platelets of diabetic patients (d-PLT) than in those of healthy subjects (h-PLT). (B) Phosphorylated Protein Kinase B (pAKT) and Phosphorylated Extracellular Signal-regulated Kinase-2 (pERK-2) were increased by collagen (Coll) and arachidonic acid (AA) stimulation in both h-PLT and d-PLT. However, the increases were higher in d-PLTs than in h-PLTs. ^###p < 0.0001 vs. basal level; ^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.005, ^∗∗∗∗p < 0.0001 vs. h-PLT (unpaired t-test and Newman–Keuls multiple-range test).