Table 1.

Ferroptosis-related genes that are transcriptionally regulated by Nrf2.

Gene symbol	Gene name	Reference
Glutathione-related
GCLM	Glutamate-cysteine ligase modifier subunit	Thimmulappa et al., 2002; Kwak et al., 2003; Lee et al., 2003
GCLC	Glutamate-cysteine ligase catalytic subunit	Thimmulappa et al., 2002; Kwak et al., 2003; Lee et al., 2003; Wu et al., 2011
GSS	Glutathione synthetase	Thimmulappa et al., 2002; Wu et al., 2011
SLC7A11	System xc-	Sasaki et al., 2002
GPX4	Glutathione peroxidase 4	Lee et al., 2003; Salazar et al., 2006; Wu et al., 2011
GSR	Glutathione reductase	Thimmulappa et al., 2002; Kwak et al., 2003; Lee et al., 2003; Wu et al., 2011
TXN1	Thioredoxin 1	Kwak et al., 2003; Lee et al., 2003
TXNRD1	Thioredoxin reductase 1	Kwak et al., 2003; Lee et al., 2003; Wu et al., 2011
Iron-related
FTH1	Ferritin heavy chain 1	Lee et al., 2003; Pietsch et al., 2003; Wu et al., 2011
FTL	Ferritin light chain	Thimmulappa et al., 2002; Lee et al., 2003; Pietsch et al., 2003; Wu et al., 2011
TFRC	Transferrin receptor 1	Lee et al., 2003
FPN1 (SLC40A1)	Ferroportin	Marro et al., 2010
MT1G	Metallothionein 1G	Sun et al., 2016a
HMOX1	Heme oxygenase 1	Alam et al., 1999; Lee et al., 2003
BLVRA	Biliverdin reductase A	Agyeman et al., 2012
BLVRB	Biliverdin reductase B	Wu et al., 2011; Agyeman et al., 2012
FECH	Ferrochelatase	Wu et al., 2011; Campbell et al., 2013
ABCB6	ATP binding cassette subfamily B member 6	Campbell et al., 2013
HRG1	Heme-response gene 1	Campbell et al., 2013
NAPDH regeneration
G6PD	Glucose-6-phosphate dehydrogenase	Thimmulappa et al., 2002; Lee et al., 2003; Wu et al., 2011
PGD	Phosphogluconate dehydrogenase	Thimmulappa et al., 2002; Wu et al., 2011
ME1	Malic enzyme 1	Thimmulappa et al., 2002; Kwak et al., 2003; Lee et al., 2003; Wu et al., 2011
Transcription factors
PPARG	Peroxisome proliferator-activated receptor gamma	Cho et al., 2010
PPARGC1A	Peroxisome proliferator-activated receptor gamma coactivator 1α	Neymotin et al., 2011