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. 2018 Jul 10;9:1444. doi: 10.3389/fimmu.2018.01444

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Copyright © 2018 Bradley, Hashimoto and Ono.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The comparative analysis of Tmem-specific and Treg-Tmem shared activation genes and T cell receptor (TCR)-dependent and activated Treg (aTreg)-specific genes. Venn diagram analysis was used to obtain intersects of TCR-dependent genes (DEG between Tcra KO and WT Treg), aTreg-specific genes (DEG between aTreg and resting Treg), and Tact-Foxp3 and Tact-Runx1 genes (see Figure 4). (A) Pie chart showing the number of genes in the intersects between aTreg-specific genes, TCR-dependent genes, and Tact-Runx1 genes. (B) Pie chart showing the number of genes in the intersects between aTreg-specific genes, TCR-dependent genes, and Tact-Foxp3 genes. (C) Pathway analysis of Tact-Foxp3 genes, Tact-Runx1 genes, and aTreg-specific genes showing enriched pathways in these gene lists.