Figure 1. Concentration-dependent inhibitory effect of triptolide on TGF-β-induced collagen gel contraction mediated by HTFs.

Cell culture was performed in collagen gels bathed in unsupplemented MEM with or without 1 ng/mL of TGF-β and a range of triptolide doses. After 3d, collagen gel contraction was determined. The experiment was repeated three times with similar results and each data point was measured in triplicate. ^aA significant difference (P<0.05, Tukey-Kramer test) between points with and without TGF-β. Error bars represent SD.