FIGURE 7.

Effect of inhaled PF670462 (day 8–21) on bleomycin-induced collagen deposition and BAL cell recruitment in mouse lungs. Female C57Bl/6 mice received intranasal bleomycin or saline on day 0. PF670462 was administered on days 8–20 by the daily inhalation of aerosol of increasing concentration from 0.3 to 3 mg/mL, for a period of 15 min once daily. Collagen content (A; measured by assessment of lung hydroxyproline content), Bronchoalveolar lavage (BAL) cell number (B) and lung fibrogenic gene expression (C) were assessed on day 21. Data are presented as mean ± SEM (n = 6 sal, n = 9–10 bleo groups). ^∗P < 0.05, ^∗∗P < 0.01, ^∗∗∗P < 0.001 from one-way ANOVA with Dunnet’s post hoc test.