Table 2.
Adverse events according to regimen
| Adverse Events | CP (n=241) | NP (n=195) | P (Grade 3-4) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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| Grade ≥1 | Grade ≥2 | Grade 3-4 | Grade ≥1 | Grade ≥2 | Grade 3-4 | ||||||||
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| N | % | N | % | N | % | N | % | N | % | N | % | ||
| Neutropenia | 195 | 80.99 | 81 | 33.6 | 109 | 55.9 | 26 | 13.3 | <0.001 | ||||
| Febrile neutropenia | 9 | 3.73 | 3 | 1.5 | 0.24 | ||||||||
| Thrombocytopenia | 42 | 17.4 | 35 | 14.5 | 31 | 15.9 | 11 | 5.6 | 0.003 | ||||
| Anemia | 139 | 57.7 | 16 | 6.6 | 92 | 47.2 | 8 | 4.1 | 0.261 | ||||
| P (Grade ≥2) | |||||||||||||
| Alopecia | 193 | 80.1 | 165 | 68.55 | 152 | 77.9 | 133 | 68.2 | 0.954 | ||||
| Nausea | 156 | 64.7 | 75 | 31.1 | 107 | 54.9 | 47 | 24.1 | 0.105 | ||||
| Vomiting | 79 | 32.8 | 34 | 14.1 | 68 | 34.9 | 33 | 16.9 | 0.418 | ||||
| Constipation | 118 | 48.9 | 32 | 13.3 | 103 | 52.8 | 27 | 13.8 | 0.863 | ||||
| Diarrhea | 72 | 29.9 | 27 | 11.2 | 63 | 32.3 | 19 | 9.7 | 0.662 | ||||
| Fatigue | 187 | 77.6 | 90 | 37.3 | 136 | 69.7 | 72 | 36.9 | 0.928 | ||||
| Neuropathy | 103 | 42.7 | 43 | 17.8 | 95 | 48.7 | 36 | 18.5 | 0.867 | ||||
| Allergy | 53 | 21.9 | 38 | 15.8 | 11 | 5.8 | 7 | 3.7 | <0.001 | ||||
Abbreviations: CP, carboplatin and paclitaxel; NP, nedaplatin and paclitaxel.