Table 4.

Additive effect of BrS-associated risk alleles on J-point elevation in lead V1.

Number of alleles	N	Mean J-point elevation in lead V1, μV	95% CI	P-value
0	428	3.5	(0.7–6.3)
1–2	3,575	7.4	(6.4–8.3)	0.0063†
3–4	1,912	8.3	(7.0–9.6)	<0.001†
5–6	69	17.1	(11.0–23.2)	<0.001†

CI, confidence interval; N, total number of individuals. Variants: SCN5A rs11708996; G/C, risk allele C, SCN10A rs6800541; C/T, risk allele C, and HEY2 rs9388451, T/C, risk allele C.

^†Statistically significant compared to zero alleles with a P-value < 0.05 with Dunnett's Post Hoc Test. Age and sex adjusted.