Table 2.
Number of LN | Entire cohort n = 893 (100%) | Stage I1n = 228 (25.5%) | Stage II1n = 444 (49.7%) | Stage IIIA1n = 221 (24.7%) |
1 LN | ||||
Patients (n) | 398 | 121 | 189 | 88 |
Median OS, mo | 18 | 24 | 20 | 10 |
3-yr SR (95%CI) | 0.503 (0.474-0.532) | 0.603 (0.553-0.653) | 0.608 (0.566-0.650) | 0.271 (0.217-0.325) |
5-yr SR (95%CI) | 0.393 (0.361-0.425) | 0.473 (0.418-0.528) | 0.445 (0.394-0.496) | 0.177 (0.128-0.226) |
2 LNs | ||||
Patients (n) | 129 | 35 | 68 | 26 |
Median OS, mo | 28 | 43 | 27 | 15 |
3-yr SR (95%CI) | 0.711 (0.665-0.757) | 0.808 (0.737-0.879) | 0.775 (0.713-0.837) | 0.425 (0.317-0.533) |
5-yr SR (95%CI) | 0.579 (0.524-0.634) | 0.725 (0.640-0.810) | 0.586 (0.504-0.668) | 0.340 (0.225-0.455) |
3 LNs | ||||
Patients (n) | 85 | 20 | 33 | 32 |
Median OS, mo | 21 | 30 | 27 | 11 |
3-yr SR (95%CI) | 0.587 (0.525-0.649) | 0.722 (0.603-0.841) | 0.697 (0.606-0.788) | 0.379 (0.277-0.481) |
5-yr SR (95%CI) | 0.466 (0.396-0.536) | 0.602 (0.454-0.750) | 0.639 (0.539-0.739) | 0.203 (0.109-0.297) |
4 LNs | ||||
Patients (n) | 55 | 8 | 31 | 16 |
Median OS, mo | 22 | 22 | 27 | 10 |
3-yr SR (95%CI) | 0.638 (0.560-0.716) | 0.833 (0.681-0.985) | 0.760 (0.671-0.849) | 0.295 (0.154-0.446) |
5-yr SR (95%CI) | 0.533 (0.438-0.628) | 0.833 (0.681-0.985) | 0.652 (0.526-0.778) | 0.148 (0.022-0.274) |
5 LNs | ||||
Patients (n) | 43 | 10 | 21 | 12 |
Median OS, mo | 24 | 38 | 24 | 18 |
3-yr SR (95%CI) | 0.750 (0.671-0.829) | 0.857 (0.725-0.989) | NA | 0.292 (0.133-0.451) |
5-yr SR (95%CI) | 0.652 (0.557-0.747) | 0.714 (0.543-0.885) | 0.857 (0.725-0.989) | 0.146 (0.016-0.276) |
≥ 6 LNs | ||||
Patients (n) | 183 | 34 | 102 | 47 |
Median OS, mo | 26 | 26 | 26 | 21 |
3-yr SR (95%CI) | 0.696 (0.655-0.737) | 0.817 (0.731-0.903) | 0.753 (0.701-0.805) | 0.498 (0.412-0.584) |
5-yr SR (95%CI) | 0.594 (0.547-0.641) | 0.817 (0.731-0.903) | 0.671 (0.610-0.732) | 0.306 (0.221-0.391) |
AJCC/TNM 8th edition. LN: Lymph node; OS: Overall survival; SR: Survival rate; NA: Not available.