Fig. 3.

Lung histopathology. Overexpressing human growth differentiation factor 15 (GDF15) in mice increases the infiltration of inflammatory cells into the lung during HRV-1B infection. Human GDF15 transgenic (hGDF15 Tg+) mice or wild-type (WT) littermates were intranasally infected with HRV-1B at 10⁷ PFU/mouse or PBS (control) for 24 h. A: representative photomicrographs of hematoxylin and eosin stained lung tissue sections for peribronchial inflammatory infiltrates (black arrow, original magnification, 200×). B: quantitative histopathology scores. Data are presented as means ± SE (n = 3–4 mice/group). *P < 0.05, compared with PBS controls or HRV-infected WT mice.