Table 3.
Summary of muscle mass or LBM estimates
| First Dosing Occasion |
Repeat Dosing Occasion |
|||||||
|---|---|---|---|---|---|---|---|---|
| N | n | Mean | SD | N | n | Mean | SD | |
| D3-creatine | ||||||||
| Method 1 (urine) | ||||||||
| HV female | 4 | 4 | 16.94 | 1.111 | 3 | 3 | 15.64 | 0.347 |
| HV male | 10 | 10 | 26.47 | 3.494 | 10 | 10 | 27.74 | 4.029 |
| CHF male | 2 | 2 | 26.82 | 5.007 | 1 | 1 | 35.37 | |
| COPD male | 2 | 2 | 28.00 | 0.688 | ||||
| Method 2 (urine) | ||||||||
| HV female | 4 | 4 | 16.31 | 1.245 | 3 | 3 | 14.71 | 0.802 |
| HV male | 10 | 10 | 25.98 | 3.581 | 10 | 10 | 27.14 | 3.510 |
| CHF male | 2 | 2 | 25.99 | 5.279 | 1 | 1 | 32.48 | |
| COPD male | 2 | 2 | 26.70 | 0.002 | ||||
| Method 3 (urine) | ||||||||
| HV female | 4 | 4 | 16.09 | 1.201 | 3 | 3 | 14.98 | 0.313 |
| HV male | 10 | 10 | 26.07 | 3.027 | 10 | 10 | 27.12 | 4.068 |
| CHF male | 2 | 2 | 27.79 | 8.576 | 1 | 1 | 30.00 | |
| COPD male | 2 | 2 | 26.48 | 0.211 | ||||
| Method 4 (plasma) | ||||||||
| HV female | 4 | 2 | 18.95 | 0.584 | 3 | 3 | 19.42 | 0.777 |
| HV male | 10 | 10 | 31.83 | 3.879 | 10 | 4 | 32.26 | 4.817 |
| CHF male | 2 | 2 | 27.48 | 6.832 | 1 | 1 | 28.99 | |
| COPD male | 2 | 2 | 26.42 | 0.189 | ||||
| MRI | ||||||||
| HV female | 4 | 4 | 18.41 | 1.897 | 3 | 3 | 17.22 | 0.701 |
| HV male | 10 | 10 | 30.24 | 4.719 | 10 | 10 | 29.77 | 4.753 |
| CHF male | 2 | 1 | 23.24 | |||||
| COPD male | 2 | 2 | 25.43 | 0.988 | ||||
| DXA | ||||||||
| Total LBM | ||||||||
| HV female | 4 | 4 | 36.39 | 2.674 | 3 | 3 | 35.88 | 1.576 |
| HV male | 10 | 10 | 54.61 | 7.285 | 10 | 10 | 54.03 | 7.418 |
| CHF male | 2 | 2 | 49.96 | 4.562 | 1 | 1 | 52.26 | |
| COPD male | 2 | 2 | 47.07 | 0.350 | ||||
| ALM | ||||||||
| HV female | 4 | 4 | 15.84 | 1.570 | 3 | 3 | 15.27 | 1.091 |
| HV male | 10 | 10 | 24.85 | 3.871 | 10 | 10 | 24.77 | 4.110 |
| CHF male | 2 | 2 | 21.86 | 3.569 | 1 | 1 | 22.99 | |
| COPD male | 2 | 2 | 20.21 | 0.264 | ||||
| 24-h UCrn (mean of 3 days) | ||||||||
| HV female | 4 | 4 | 12.43 | 1.470 | 3 | 3 | 12.97 | 1.234 |
| HV male | 10 | 10 | 20.62 | 3.216 | 10 | 10 | 22.03 | 3.366 |
| CHF male | 2 | 2 | 15.23 | 3.496 | 1 | 1 | 14.60 | |
| COPD male | 2 | 2 | 20.10 | 1.399 | ||||
Values are expressed in kg. LBM, lean body mass; N, total group size; n, number of subjects who provided data used to calculate mean; ALM, appendicular lean mass; SD, standard deviation; MRI, magnetic resonance imaging; DXA, dual-energy X-ray absorptiometry; 24-h UCrn; 24-h urinary creatinine excretion.