Fig. 2.

Efficacy of insulin-CAGE in lowering blood glucose levels upon intrajejunal administration in nondiabetic rats. (A) Blood glucose lowering efficacy of various formulations compared with initial levels. (B) Blood glucose changes after normalizing for fasting effect related blood glucose changes. Animals injected with saline alone were considered as the fasting group, and data were plotted after subtracting the blood glucose obtained from the saline group. All data are represented as mean ± SE (n = 6). A significantly higher (P < 0.05) efficacy was noted in the efficacy of 5 U/kg insulin-CAGE–treated rats at various time points of the study compared with s.c. administered 2 U/kg insulin (represented by asterisks).