Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jun 26;115(28):E6566–E6575. doi: 10.1073/pnas.1800727115

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Published under the PNAS license.

PMC Copyright notice

Fig. 5. — Functional and structural impairment in homozygous Mhc^K1728del larval heart muscles. (A) Heart muscles of third-instar larvae were labeled for Mhc and Kettin/Titin. Heart muscle of heterozygous Mhc^K1728del/+ mutant (Middle) shows normal sarcomeric striated patterns, compared with control (Top). Homozygous Mhc^K1728del/Mhc^K1728del larval heart muscle (Bottom) exhibits disturbed sarcomere structures with disorganised Z-disks and diffuse Kettin-staining. (Scale bar, 5 µm.) (B) Heart rate assessment: Heterozygous Mhc^K1728del/+ animals show no significant changes in heart rate compared with controls. Homozygous Mhc^K1728del/Mhc^K1728del larvae show significantly lower heart rate compared with control and heterozygous Mhc^K1728del/+ animals (P < 0.0001). Twenty larvae of each group were analyzed in triplicate. ns, P > 0.05; **P < 0.001.