WM microstructure differs between wild and domestic rabbits. More than 50% of the voxels in the WM regions corona radiata (A), subcortical WM (B), and corpus callosum (C) displayed reduced fractional anisotropy in domestic rabbits. Areas within each principal WM structure are highlighted in color and shown as (1) tilted frontal side view (Right) of the rabbit brain, (2) rostral frontal view, and (3) tilted frontal side view (Left). These findings support that domestication compromises WM integrity in both association and projection fibers. This affects afferent and efferent neural flow of the rabbit brain, implicating reduced information processing capacity both between and within hemispheres.