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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Stem Cells. 2017 Jun 27;35(8):1913–1923. doi: 10.1002/stem.2646

Figure 4.

Figure 4

YY1 overexpression maintains CPC gene expression. Microarray expression profiling of FACS-purified eGFP+ CPCs at day 6 of in vitro differentiation (Day 6 GFP) and purified eGFP+ cells that have been cultured for 4 additional days in the presence (Day 10 +Dox) or absence (Day 10 −Dox) of doxycycline. (A) Comparison of gene expression between Day 6 CPCs and Day 10 cells that have been treated with or without doxycycline. Genes showing greater than a 2-fold increase or decrease in expression are located outside the indicated lines. (B) Comparison of gene expression between Day 6 CPCs and Day 10 cells not treated with doxycycline. (C) Heat map showing the overall gene expression profile of Day 6 CPCs and CPCs that have been cultured for 4 days with or without doxycycline. (D) Quantitative PCR analysis of sarcomeric gene expression in differentiating CPCs with or without doxycycline treatment. P<0.001, (**) P<0.05.