Table 2.
Cumulative table of published national and international stroke registries providing data on the outcome of acute stroke patients treated with intravenous thrombolysis.
| Greece | Italy12 | Austria 13 | Belgium14 | Poland15 | SITS-EAST10 | SITS-ISTR16 | SITS-MOST4 | |
|---|---|---|---|---|---|---|---|---|
| Patients (N) | 523 | 586 | 896 | 743 | 481 | 19077 | 12529 | 6483 |
| Age (years, IQR) | 63 (55–72) | 68 (21–80) | 70 (60–77) | 71 | 66 (59–75) | 70 (61–77) | 68 | 68 (59–75) |
| Females (%) | 34.6% | 39.4% | 44.6% | 47% | 41% | 44.1% | 39.2% | 39.8% |
| Therapeutic window (hours) | 0–4.5 | 0–3 | 0–4.5 | 0–4.5 | 0–4.5 | 0–4.5 | 0–3/3–4.5*** | 0–3 |
| Admission NIHSS (IQR) | 11 (7–17) | 13 (2–25) | 13 (8–18) | 14 (9–19) | 11 (7–17)** | 11 (7–16) | 12 | 12 (8–17) |
| Stroke onset-to-treatment time (min, IQR) |
150 (120–180) |
152 (40–180) |
135 (105–160) |
140 (N/A) |
160 (130–175) |
150 (120–180) |
140 (N/A) |
140 (115–165) |
| sICH – NINDS (%, 95%CI) |
3.8% (1.5–6.7%) |
6.7% (4.8–9.1%) |
N/A | 9.5% (7.5–11.9%) |
7.0% (5.0–9.7%)* |
N/A | 7.3% (6.9–7.8%) |
7.3% (6.7–7.9%) |
| sICH – ECASS (%, 95%CI) |
2.3% (0.8–5.5%) |
4.5% (2.9–6.5%) |
7.6% (6–9.6%) |
6.9% (5.1–9%) |
N/A | 4.9% (4.6–5.2%) |
4.8% (4.5–5.2%) |
4.6% (4.1–5.1%) |
| sICH – SITS-MOST (%, 95%CI) |
1.4% (0.3–4.2%) |
1.2% (0.5–2.5%) |
1.6% (0.9–2.6%) |
2.4% (1.4–3.7%) |
1.2% (0.5–2.8%)* |
1.8% (1.6–2.0%) |
1.6% (1.4–1.8%) |
1.7% (1.3–2.0%) |
| 3-month FFO (%, 95%CI) |
55.6% (51.1–60.1%) |
40.6% (36.6–44.7%) |
38.1% (34.8–41.6%) |
29.2% (25.8–32.9%) |
N/A | 42.4% (41.5–43.3%) |
39.9% (39.0–40.9%) |
38.9% (37.7–40.1%) |
| 3-month FI (%, 95%CI) |
66.5% (62.0–70.7%) |
51.6% (47.4–55.7%) |
50.8% (47.2–54.4%) |
44% (39.5–47.5%) |
54% (50–59%)* |
50.7% (49.9–51.6%) |
56.3% (55.4–57.3%) |
54.8% (53.5–56.0%) |
| 3-month mortality (%, 95%CI) |
7.9% (5.8–10.7%) |
11.7% (9.2– 14.6%) |
12.1% (9.9–14.5%) |
23% (19.6–26.3%) |
18.6% (15.3–22.5%)* |
12%, (11.5–12.6%) |
12.2% (11.6–12.8%) |
11.3% (10.5–12.1%) |
Due to the report of percentages instead of absolute values the 95% CI for Poland have been estimated approximately.
mean value (95% CI).
For the SITS-ISTR cohort we present pooled data from both the 0–3 h and 3–4.5 h cohorts.
CI, confidence interval; EAST, EAST registry; ECASS, European Cooperative Acute Stroke Study; FI, functional independence (defined as a modified Rankin scale score ⩽2); IQR, interquartile range; ISTR, International Stroke Thrombolysis Register; MOST, Monitoring Study; NIHSS, National Institutes of Health Stroke Scale; NINDS, National Institute of Neurological Disorders and Stroke; SITS, Safe Implementation of Treatments in Stroke.