. 2018 Jul 16;11:1756284818785573. doi: 10.1177/1756284818785573

Table A3.

Details of intervention and adverse events among included systematic reviews.

Author(s)	Intervention (dosage, frequency)	Control (dosage, frequency)	Adverse Events
Liu et al.³⁸	(1) Jian Pi Yi Qi formula (NR); (2) Li Qi Fu Wei solution (NR); (3) Jian Pi Xiao Zhang granule (NR); (4) He Wei Xiao Pi capsule (NR)	(1) Mosapride (NR); (2) Domperidone (NR)	NR
Qin et al.³¹	(1) Modified Xiao Yao San (dosage: NR, q.d./ b.i.d.); (2) Modified Xiao Yao San (dosage: NR, b.i.d.) + domperidone (10 mg, t.i.d.); (3) Modified Xiao Yao San (dosage: NR, b.i.d.) + deanxit (1–2 tablets, t.i.d.); (4) Modified Xiao Yao San (dosage: NR, b.i.d.) + mosabilium (5 mg, t.i.d.)	(1) Domperidone (10 mg, t.i.d.); (2) Domperidone (10 mg, t.i.d.) + oryzanol (20 mg, t.i.d.); (3) Deanxit (1–2 tablets, t.i.d.); (4) Mosabilium (5 mg, t.i.d.)	Sleepiness, insomnia, passage of small amount loose stools
Cui and Shen²⁹	Details of CHM are not reported	(1) Domperidone (NR); (2) Mosapride (NR)	NR
Wang et al.³⁰	(1) Gan Wei Shu capsule (three capsules, t.i.d., p.o.) (2) Chai Hu Shu Gan powder/decoction (NR) (3) He Wei Xiao Yao decoction (NR) (4) Jia Wei Si Ni powder (NR) (5) Xing Qi Tong Jian pill (4 Pills, t.i.d., p.o.) + Ju Pi porridge (NR) (6) Li Qi He Wei oral liquid (10 ml, t.i.d., p.o.) (7) Jiang Qi He Zhong decoction (NR) (8) Shu Wei decoction (NR) (9) Jian Pi Shu Gan decoction (NR) (10) Shu He decoction (NR) (11) Modified Si Ni powder (NR) (12) Shu Gan Jian Pi formula and acupuncture (NR)	(1) Domperidone (10 mg t.i.d.); (2) Mosapride (5 mg, t.i.d.); (3) Polyzyme tablets (three tablets, t.i.d.)	Intervention group: epigastric discomfort and increased passing of flatus
Xiao et al.³²	(1) Xiang Sha Liu Jun Zi decoction (dosage: NR, b.i.d.); (2) Liu Jun Zi decoction (dosage: NR, b.i.d.)	(1) Domperidone (10 mg, t.i.d.); (2) Mosapride (5 mg, t.i.d.)	Control group: Tolerable: abdominal pain, diarrhea, rugitus, loose stools
Xiao et al.³³	Shu Gan Jie Yu capsule (dosage: NR, b.i.d.) + mosapride (5 mg, t.i.d.)	Mosapride (5 mg, t.i.d.)	Intervention group: gastrointestinal discomfort, dry mouth, dizziness Control group: dry mouth, diarrhea, dizziness Both groups: Mild and tolerable: increasing frequency of defecation
Yang et al.³⁴	(1) Modified Chai Hu Shu Gan powder (dosage: NR, b.i.d.); (2) Modified Chai Hu Shu Gan powder (dosage: NR, b.i.d.) + mosapride (5 mg, t.i.d.); (3) Modified Chai Hu Shu Gan powder (dosage: NR, b.i.d.) + flupentixol melitracen tablets (one pill, q.d.); (4) Modified Chai Hu Shu Gan powder (dosage: NR, b.i.d.) + domperidone (10 mg, t.i.d.); (5) Modified Chai Hu Shu Gan powder (dosage: NR, b.i.d.) + trimebutine maleate tablets (100 mg, q.d.)	(1) Domperidone (10 mg, t.i.d.); (2) Trimebutine maleate tablets (100 mg, q.d.); (3) Flupentixol melitracen tablets (two pills, q.d.); (4) Domperidone (10 mg, t.i.d.) + compound azintamide Tablets (1–2 Pills, t.i.d.); (5) Mosapride (5 mg, t.i.d.)	Reported as no adverse events
Gan et al.³⁵	Ban Xia Xie Xin decoction (NR)	(1) Domperidone (NR) (2) Mosapride (NR)	Control group: gastrointestinal symptoms, headache
Fan and He³⁶	Da Li Tong granule (6 g, t.i.d.)	(1) Mosapride (5 mg, t.i.d.); (2) Domperidone (10 mg, t.i.d.)	Intervention group: abdominal fullness Control group: abdominal pain, dizziness, diarrhea, borborygmi
Liu²⁵	(1) Xiao Pi formula no. 1 or 2 (NR) (2) Li Zhong decoction (NR) (3) Jian Pi Xiao Zhang powder decoction (NR) (4) Xiang Sha Liu Jun Zi decoction (NR) (5) He Wei Xiao Pi capsules (NR) (6) He Wei powder (NR) (7) San Jiu Wei Tai granule (NR) (8) Chai Hu Shu Gan San (NR) (9) Qing Song decoction (NR) (10) Shu Gan Yang Xin decoction (NR) (11) Huo Xiang Zheng Qi capsule (NR) (12) Ban Xia Xie Xin decoction (NR) (13) Can Ling Bai Shu San (NR) (14) Zuo Jin decoction (NR) (15) San Xiang decoction (NR) (16) Jian Wei Xiao Zhang granule (NR) (17) Si Ni San (NR) (18) Da Li Tong granule (NR) (19) Ping Wei capsule (NR) (20) Xiao Yao San (NR) (21) He Wei An Xiao decoction (NR) (22) Shu Gan Jie Yu capsule (NR)	(1) Details of placebo are not reported; (2) Prokinetic agents/H2 receptor/antagonists/antidepressants (NR)	NR
Zhang²⁷	(1) Ban Xia Xie Xin decoction (NR) (2) Si Ni Xiexin decoction (NR) (3) Xiao Pi Tong Jiang decoction (NR) (4) Chai Hu Wen Dan decoction (NR) (5) Zhi Shi Xiao Pi decoction (NR) (6) Fu He Xie Xin decoction (NR) (7) Chai Zhi Ban Xia Xie Xin decoction (NR)	(1) Domperidone (NR); (2) Trimebutine (NR); (3) Mosapride (NR); (4) Omeprazole (NR)	NR
Akarayosapong³⁷	Liu Wei An Xiao capsule (500 mg × 2–6 pills, t.i.d.)	(1) Mosapride (5 mg, t.i.d.); (2) Domperidone (10 mg, t.i.d.); (3) Metoclopramide (10 mg, t.i.d.); (4) Digestive enzymes (500 mg, two pills t.i.d.); (5) Domperidone (10 mg, t.i.d.) + oryzanol (20 mg, t.i.d.); (6) Domperidone (10 mg, t.i.d.) + doxepin (12.5 mg, t.i.d.); (7) Flupentixol + melitracen (one pill, b.i.d.); (8) Domperidone (10 mg, t.i.d.) + amoxicillin (0.5 g, t.i.d.)	Intervention group: more frequent egestion Control group: constipation, dizziness, insomnia Both groups: abdominal pain, borborygmi, more frequent urination, loose stool, diarrhea, headache
Ling et al.²⁸	Si Ni San (NR)	(1) Domperidone (NR); (2) Domperidone + deanxit (NR); (3) Domperidone + oryzanol (NR); (4) Mosapride (NR)	Mild and tolerable nausea, vomiting, abdomen discomfort
Guo et al.²⁶	(1) Ri Kun Shi To powder (2.5 g, t.i.d.) (2) Gastrosis no. 3 compound granules (150 ml, b.i.d.) (3) Qing Hua He Wei Tablets (four tablets, 1.2 g, t.i.d.) (4) Gastrosis no. 1 compound granules (150 ml, b.i.d.) (5) Ban Xia Xie Xin Tang granules (150 ml, b.i.d.) (6) Modified Liu Jun Zi Tang granules (150 ml, b.i.d.) (7) Nos.1–4 compound granules (b.i.d./t.i.d.) (8) Ban Ha Sa Si decoction (3 g, t.i.d.) (9) Yang Sa Yang Wei San powder (9.68 g, t.i.d.)	Placebo in the forms of powder (2.5 g/9.68 g, t.i.d.), granule (150 mL/3 g, b.i.d./t.i.d.) or tablets (four pills, 1.2 g, t.i.d.)	NR

NR, not reported; CHM, Chinese herbal medicine; b.i.d., twice a day; t.i.d., three times a day; q.d., once a day.