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. 2018 Jun 27;17:1533033818780091. doi: 10.1177/1533033818780091

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© The Author(s) 2018

This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://www.creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 1. — Increased expression of IL-33 and ST2L in the serum or tissue of CT26 tumor-bearing mice the mRNA levels of IL-33 (A), soluble ST2 (C), and ST2L (D) in the serum of WT and tumor-bearing mice were evaluated by qRT-PCR. The protein levels of IL-33 (B) and soluble ST2 (E) in the serum of WT and tumor-bearing mice were evaluated by ELISA. The mRNA levels of IL-33 (F), soluble ST2 (H), and ST2L (I) in the tumors or surrounding nontumor muscular tissues (SNMT) of tumor-bearing mice were evaluated by qRT-PCR; the protein levels of IL-33 (G) and soluble ST2 (J) in the tumor or SNMT homogenates of tumor-bearing mice were evaluated by ELISA. Data are from two independent experiments (mean [SD]), in which each experimental group contained 6 mice. ***P < .001 as compared to the control group (Student t test). **P < .01 as compared to the control group (Student t test). Pearson correlation analysis showed a correlation between the expression of normalized IL-33 or soluble ST2 (the protein levels/tumor volume) in the tumors and tumor volume (P < .05) (K, L). IL indicates interleukin; qRT-PCR, quantitative reverse transcription polymerase chain reaction; ELISA, enzyme-linked immunosorbent assay; SD, standard deviation.