Table 3.
Results of TNF-α Promoter Gene SNP Genotype by Group.a
| Group | N | rs361525 (N) | χ2/P b | rs1800629 (N) | χ2/P b | rs1800750 (N) | χ2/P b | rs1799964 (N) | χ2/P b | rs673 (N) | χ2/P b | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CC | CT | TT | GG | AG | AA | GG | AG | AA | GG | AG | AA | GG | AG | AA | |||||||
| Control | 494 | 475 | 19 | 0 | 424 | 70 | 0 | 492 | 2 | 0 | 410 | 81 | 3 | 483 | 11 | 0 | |||||
| Cervical squamous cell carcinoma | 452 | 403 | 49 | 0 | χ2 = 20.707 | 317 | 135 | 0 | χ2 = 34.916 | 450 | 2 | 0 | χ2 = 2.539 | 275 | 173 | 4 | χ2 = 57.396 | 440 | 12 | 0 | χ2 = 0.212 |
| Carcinoma In situ | 104 | 97 | 7 | 0 | P < .001 | 76 | 28 | 0 | P < .001 | 104 | 0 | 0 | P = .281 | 67 | 37 | 1 | P < .001 | 101 | 3 | 0 | P = .899 |
| Invasive carcinoma | 348 | 306 | 42 | 0 | 241 | 107 | 0 | 344 | 4 | 0 | 212 | 136 | 3 | 339 | 9 | 0 | |||||
Abbreviations: TNF-α, tumor necrosis factor-α; SNP, single nucleotide polymorphisms.
a C-cytosine; T-thymidine; A-adenine, and G-guanine. The base pair of rs361525 gene is C and T, where CC and TT being homozygous and CT being heterozygous; the base pair for other 4 SNP sites were all G, A, GG, and AA being homozygous, and AG being heterozygous.
b Used the Cochran-Mantel-Haenszel (CMH) test.