Table 4.
Allele Frequencies of the 5 SNPs of TNF-α Promoter Gene by Groups.a
| SNPs | Allele frequency | χ2/P b | OR (95% CI) | P | |||||
|---|---|---|---|---|---|---|---|---|---|
| Control group (N = 494) | Cervical Cancer group (N = 452) | ||||||||
| Homozygous | Heterozygous | Homozygous | Heterozygous | G/(C*) | A/(T*) | G/(C*) | A/(T*) | ||
| rs361525 | 0.962 (475) | 0.038 (19) | 0.892 (403) | 0.108 (49) | χ2 = 17.3/P < .001 | 0.33 (0.19-0.57) | 3.04 (1.76-5.25) | <.01 | <.01 |
| rs1800629 | 0.858 (424) | 0.142 (70) | 0.701 (317) | 0.299 (135) | χ2 = 34.3/P < .001 | 0.39 (0.28-0.54) | 2.58 (1.87-3.56) | <.01 | <.01 |
| rs1800750 | 0.996 (492) | 0.004 (2) | 0.996 (450) | 0.004 (2) | χ2 = 0.008/P = 0.929 | 1.09 (0.15-7.79) | 0.92 (0.13-6.52) | .929 | .929 |
| rs1799964 | 0.836 (413) | 0.164 (81) | 0.617 (279) | 0.383 (173) | χ2 = 57.52/P < .001 | 0.32 (0.23-0.43) | 3.16 (2.33-4.28) | <.01 | <.01 |
| rs673 | 0.978 (483) | 0.022 (11) | 0.973 (440) | 0.027 (12) | χ2 = 0.182/P = 0.669 | 0.84 (0.37-1.91) | 1.20 (0.52-2.74) | 0.6697 | 0.6697 |
Abbreviations: OR, odds ratio; SNP, single nucleotide polymorphisms; TNF-α, tumor necrosis factor-α.
a OR using the recessive genetic model (OR = 1, indicating that the factor does not influence the occurrence of the disease; OR > 1, indicating that the factor is a risk factor; OR < 1, indicating that the factor is protective factors). The allele base of the rs361525 allele is C, T, CC, and TT being homozygous, CT being heterozygous; the other 4 sites are G, A, GG, and AA being homozygous, and AG being heterozygous.
b Used χ2 test.