Table 5.
Comparison of Genotype and Allele Frequency of 5 Loci Between Patients With CIS and IC.
| SNP Locus | Group | N | Genotype Frequency (%) | χ2/P a | Allele Frequency (%) | χ2/P b | |||
|---|---|---|---|---|---|---|---|---|---|
| CC/GG | CT/GA | TT/AA | C/G | T/A | |||||
| rs361525 | Carcinoma in situ | 104 | 97 (93.3) | 7 (6.7) | 0 (0.0) | χ2 = 2.356/P = .1248 | 201 (96.6) | 7 (3.4) | χ2 = 2.225/P = .1358 |
| Invasive cancer | 348 | 306 (87.9) | 42 (12.1) | 0 (0.0) | 654 (94.0) | 42 (6.0) | |||
| rs1800629 | Carcinoma in situ | 104 | 76 (73.1) | 28 (26.9) | 0 (0.0) | χ2 = 0.558/P = .4552 | 180 (86.5) | 28 (13.5) | χ2 = 9.474/P = .002 |
| Invasive cancer | 348 | 241 (69.3) | 107 (30.7) | 0 (0.0) | 589 (93.3) | 42 (6.7) | |||
| rs1800750 | Carcinoma in situ | 104 | 104 (100.0) | 0 (0.0) | 0 (0.0) | χ2 = 1.203/P = .2726 | 208 (100.0) | 0 (0.0) | P = .5790c |
| Invasive cancer | 348 | 344 (98.9) | 4 (1.1) | 0 (0.0) | 692 (99.4) | 4 (0.6) | |||
| rs1799964 | Carcinoma in situ | 104 | 66 (64.3) | 37 (35.6) | 1 (0.01) | χ2 = 0.414/P = .8117 | 171 (81.4) | 39 (18.6) | χ = 0.279/P = .5971 |
| Invasive cancer | 348 | 209 (60.0) | 136 (39.1) | 3 (0.9) | 692 (83.0) | 142 (17.0) | |||
| rs673 | Carcinoma in situ | 104 | 101 (97.1) | 3 (2.9) | 0 (0.0) | χ2 = 028/P = .8682 | 205 (98.6) | 3 (1.4) | χ2 = 0.000/P = 1.000d |
| Invasive cancer | 348 | 339 (98.9) | 9 (1.1) | 0 (0.0) | 692 (98.7) | 9 (1.3) | |||
Abbreviations: CIS, carcinoma in situ; IC, invasive carcinoma; SNP, single nucleotide polymorphisms.
a Using Cochran-Mantel-Haenszel (CMH) test.
b Using χ2 test.
c Using Fisher test.
d Use continuity correction card.