Table 3.
Treatment-Related Toxicities (Grade 3 or 4).
| Toxicity | SBRT Alone (n = 28) | SBRT + TACE (n = 122) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Baseline | Post-SBRT | Baseline | Post-TACE | Post-SBRT | ||||||
| 3 | 4 | 3 | 4 | 3 | 4 | 3 | 4 | 3 | 4 | |
| Elevated total bilirubin | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 2 | 0 |
| Elevated AST/ALT | 0 | 0 | 0 | 0 | 0 | 0 | 11 | 0 | 1 | 0 |
| Decreased platelet count | 2 | 0 | 3 | 1 | 9 | 0 | 17 | 0 | 16 | 2 |
| Decreased albumin | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 |
| Ascites | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 |
| Portal vein thrombosis | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
| Radiation pneumonitis | – | – | 0 | 0 | – | – | – | – | 0 | 0 |
| Other toxicitya | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 2 | 0 |
| Total | 2 | 0 | 4 | 1 | 10 | 0 | 31 | 0 | 21 | 2 |
Abbreviations: AST/ALT, aspartate aminotransferase/alanine aminotransferase; TACE, transcatheter arterial chemoembolization; SBRT, stereotactic body radiotherapy.
a Include elevated γglutamyl transpeptidase, bile duct stenosis, and hepatic encephalopathy.