Table 6.
Prognostic Factor | All Patients (n = 150) | SBRT Alone (n = 28) | SBRT + TACE (n = 122) | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Number | 2-Year OS (%) | UVA, P Value | MVA, P Value | Number | 2-Year OS (%) | UVA, P Value | MVA, P Value | Number | 2-Year OS (%) | UVA, P Value | MVA, P Value | ||
Age, years | ≧75 | 73 | 35.9 | .1027 | − | 16 | 63.6 | .9466 | − | 57 | 30.7 | .0643 | − |
<75 | 77 | 51.1 | 12 | 39.3 | 65 | 52.4 | |||||||
Gender | Male | 99 | 42 | .825 | − | 17 | 24.5 | .1219 | − | 82 | 44.1 | .5285 | − |
Female | 51 | 47.5 | 11 | 80.8 | 40 | 39.9 | |||||||
Performance status | 0 | 128 | 40.9 | .1242 | − | 21 | 40.1 | .0826 | − | 107 | 40.9 | .5434 | − |
1 or 2 | 22 | 68.7 | 7 | 100 | 15 | 57 | |||||||
CTP class | A | 127 | 46.6 | .0936 | − | 23 | 52.3 | .8956 | − | 104 | 45.3 | .0484 | .028 |
B | 23 | 31.9 | 5 | 37.5 | 18 | 29.3 | |||||||
Viral infection | HCV | 109 | 39.7 | .0025 | .0017 | 18 | 58.2 | .8181 | − | 91 | 36.7 | .0017 | .001 |
Non-HCV | 41 | 56.3 | 10 | 38.6 | 31 | 62.4 | |||||||
BCLC stage | 0 | 80 | 48.8 | .2006 | − | 17 | 40.1 | .4716 | − | 63 | 50 | .0946 | − |
A | 70 | 38.8 | 11 | 62.3 | 59 | 35 | |||||||
T stage | T1 | 113 | 52.3 | .001 | .0203 | 24 | 50.9 | .6021 | − | 89 | 52.3 | <.0001 | .012 |
T2 | 37 | 18.3 | 4 | 50 | 33 | 13.5 | |||||||
Greatest tumor dimensions | ≧20 mm | 63 | 42.5 | .8397 | − | 12 | 49.1 | .972 | − | 47 | 38.6 | .8236 | − |
<20 mm | 87 | 45.4 | 12 | 43 | 75 | 45.4 | |||||||
Tumor location | Central | 13 | 49.4 | .32 | − | 4 | 33.3 | .4061 | − | 9 | 40.6 | .1224 | − |
Periferal | 137 | 43.5 | 24 | 61.9 | 113 | 77.8 | |||||||
Diagnosis history | Initial | 36 | 62 | .0194 | .0153 | 13 | 72.9 | .0396 | − | 23 | 56.6 | .1365 | − |
Recurrence | 114 | 38.7 | 15 | 28.4 | 99 | 39.6 | |||||||
Previous treatment (surgery) | Yes | 61 | 37.7 | .0891 | − | 9 | 31.1 | .0773 | − | 52 | 38.8 | .256 | − |
No | 89 | 48.9 | 19 | 59 | 70 | 46.1 | |||||||
Previous treatment (RFA/PEI) | Yes | 41 | 37.5 | .1796 | − | 5 | 33.3 | .2962 | − | 35 | 38.1 | .2956 | − |
No | 109 | 46.6 | 23 | 54.4 | 87 | 44.6 | |||||||
Adverse effects | <Grade 3 | 122 | 46.4 | .6421 | − | 23 | 48.8 | .43 | − | 99 | 45.6 | .3302 | − |
≧Grade 3 | 28 | 34.8 | 5 | 53.3 | 23 | 30.4 | |||||||
Combination with TACE | Yes | 28 | 49 | .1889 | − | ||||||||
No | 122 | 42.9 |
Abbreviations: BCLC; Barcelona Clinic Liver Cancer; CTP; Child-Turcotte-Pugh; HCV; hepatitis C virus; MVA, multivariate analyses; OS, overall survival; PFS, progression-free survival; RFA/PEI; radiofrequency ablation/percutaneous ethanol injection; SBRT, stereotactic body radiotherapy; TACE, transcatheter arterial chemoembolization; UVA, univariate analyses.