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. 2018 Jul 11;10:1758835918783132. doi: 10.1177/1758835918783132

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© The Author(s), 2018

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 2. — Microribonucleic acid-451 is silenced in tumor tissues and correlated with poor prognosis of patients with metastatic castration-resistant prostate cancer.

(a) miR-451 expression detected by qRT-PCR in normal prostate tissues (n = 18) and tumor tissues (n = 59); the cut-off value (0.895) of tumor tissues was determined by an ROC curve; (b) miR-451 expression levels in normal prostate tissues and prostate cancer tissues of varying Gleason scores; (c) Kaplan–Meier analysis of the correlation between miR-451 expression and PFS of mCRPC patients; (d) Kaplan–Meier analysis of the association between miR-451 expression and OS of mCRPC patients.

^*p < 0.05; ^#p < 0.05, ^##p < 0.01.

mCRPC, metastatic castration-resistant prostate cancer patients; miR-451, microribonucleic acid-451; OS, overall survival; PFS, progression-free survival; qRT-PCR, quantitative reverse-transcription polymerase chain reaction; ROC, receiver operating characteristic.