Fig. 2.

Inactivation of GC-A in pancreatic β-cells (β GC-A KO) does not alter physiological stimulus-secretion coupling in vivo. a Fasting (basal) or random fed and b oral glucose-stimulated plasma insulin levels (GSIS) were determined in 4 months old GC-A KO and control littermates (n = 13 mice/genotype). c, d Blood glucose concentration and area under the curve (AUC, right panels) during oral (c oGTT (n = 13 per genotype) or IP glucose tolerance tests (d ipGTT (n = 8 per genotype). GTTs were performed in 16-h-fasted 4 months old β GC-A KO and control littermates. *P < 0.01 vs fasted or basal