Table 2.

Flea counts on naturally infested dogs in households in Florida before and after treatment with a single oral dose of fluralaner or three consecutive monthly doses of sarolaner

Treatment group	No. of dogs on day 0		Days post-treatment
			0	7	14	21	28–30	40–45	56–60	82–86
Fluralaner1	18	Geomean flea count3	26.9b,x	0.1a,y	0.3a,y	0.1a,y	0.0a,y	0.1a,y	0.0a,y	0.0a,y
		Range	(5–131)	(0–1)	(0–3)	(0–2)	(0–0)	(0–2)	(0–0)	(0–0)
		% control4		99.7	99.0	99.8	100	99.6	100	100
		% (#) dogs with no fleas	0.0a,x (0/18)	88.9a,y (16/18)	72.2a,y (13/18)	94.4a,y (17/18)	100a,y (18/18)	88.9a,y (16/18)	100a,y (18/18)	100a,y (18/18)
Sarolaner2	13	Geomean flea count3	37.9a,x	0.1a,y	0.1a,y	0.2a,y	0.1a,y	0.0a,y	0.0a,y	0.0a,y
		Range	(10–171)	(0–1)	(0–1)	(0–2)	(0–1)	(0–0)	(0–0)	(0–0)
		% control4		99.7	99.8	99.4	99.9	100	100	100
		% (#) dogs with no fleas	0.0a,x (0/13)	84.6a,y (11/13)	91.7a,y (11/12)	76.9a,y (10/13)	92.3a,y (12/13)	100a,y (13/13)	100a,y (13/13)	100a,y (12/12)

¹In the fluralaner group dogs were treated once orally on day 0 (Bravecto chew; Merck Animal Health, Madison, NJ, USA)

²In the sarolaner group dogs were treated on day 0 and once between days 28–30 and 56–60 (Simparica chew; Zoetis, Whippany, NJ, USA)

³Geometric mean numbers of fleas in area counts

⁴{(Day 0 geometric mean animal area flea counts – day x geometric mean animal area flea counts) / day 0 geometric mean animal area flea counts)} × 100

^a,bGeometric mean flea counts in a column with unlike letter superscripts are significantly different (day 0, P = 0.034; │t│ = 2.14 )

^x,yGeometric mean flea counts in a row with unlike letter superscripts are significantly different from day 0 (P < 0.001; │t│ ≥ 22.83)

^a,bPercent of flea- free dogs in a column with like letter superscripts are not significantly different (P > 0.284; Fisher’s exact test)

^x,yPercent of flea- free dogs in a row with unlike letter superscripts are significantly different from day 0 (P < 0.001; Fisher’s exact test)