Table 3.
Fleas caught in intermittent-light flea traps in naturally infested homes in Florida before and after treatment of all dogs and cats in the homes with either a single administration of fluralaner or three consecutive monthly administrations of sarolaner (dogs) and selamectin (cats)
| Treatment group | Days post-treatment | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 0 | 7 | 14 | 21 | 28–30 | 40–45 | 56–60 | 82–86 | |||
| Fluralaner1 | 20 homes on study | |||||||||
| Geomean flea count3 | 32.4a,x | 6.3a,y | 7.2a,y | 1.6b,y | 0.5a,y | 0.2a,y | 0.1a,y | 0.04a,y | ||
| Range | (5–183) | (0–113) | (0–156) | (0–19) | (0–6) | (0–5) | (0–1) | (0–1) | ||
| % control4 | 80.4 | 77.9 | 95.0 | 98.4 | 99.4 | 99.8 | 99.9 | |||
| % (#) homes with 0 fleas in traps | 0.0a,x (0/20) | 10.5a,x (2/19) | 20.0a,x (4/20) | 30.0a,y (6/20) | 70.0a,y (14/20) | 85.0a,y (17/20 | 90.0a,y (18/20) | 95.0a,y (19/20) | ||
| % (#) homes with no fleas (traps, cats or dogs) | 0.0a,x (0/20) | 15.0a,x (3/20) | 15.0a,x (3/20) | 30.0b,y (6/20) | 60.0b,y (12/20) | 75.0b,y (15/20) | 80.0b,y (16/20) | 95.0b,y (19/20) | ||
| Selamectin/Sarolaner2 | 18 homes on study | Geomean flea count3 | 28.0a,x | 4.7a,y | 4.8a,y | 4.2a,y | 1.4a,y | 0.04a,y | 0.4a,y | 0.4a,y |
| Range | (5–152) | (0–195) | (0–93) | (0–22) | (0–1) | (0–14) | (0–39) | (0–12) | ||
| % control4 | 83.1 | 82.7 | 85.0 | 95.1 | 99.9 | 98.8 | 98.5 | |||
| % (#) homes with 0 fleas in traps | 0.0a,x (0/18) | 16.7a,x (3/18) | 17.6a,x (3/17) | 22.2a,x (4/18) | 44.4a,y (8/18) | 94.1a,y (16/17) | 82.4a,y (14/17) | 68.8a,y (11/16) | ||
| % (#) homes with no fleas (traps, cats or dogs) | 0.0a,x (0/18) | 5.6a,x (1/18) | 16.7a,x (3/18) | 0.0a,x (0/18) | 5.6a,x (1/18) | 23.5a,y (4/17) | 29.4a,y (5/17) | 31.3a,y (5/16) | ||
1In the fluralaner group dogs were treated once orally on day 0
2In the selamectin/sarolaner group cats and dogs were treated on day 0 and again between days 28–30 and between days 56–60
3Geometric mean numbers of fleas recovered in two intermittent light flea traps averaged within households
4{(Day 0 geometric mean animal area flea counts – day x geometric mean animal area flea counts) / day 0 geometric mean animal area flea counts)} × 100
a,bGeometric mean trap flea counts in a column with unlike letter superscripts are significantly different (Day 21; P=0.032; │t│ = 2.18)
x,yGeometric mean trap flea counts in a row with unlike letter superscripts are significantly different from day 0 (P < 0.001; │t│ ≥ 5.57)
a,bPercent of flea- free traps in a column with like letter superscripts are not significantly different (P > 0.069; Fisher’s exact test).
x,yPercent of flea- free traps in a row with unlike letter superscripts are significantly different from day 0 (P < 0.020; Fisher’s exact test)
a,bPercent of flea- free homes in a column with unlike letter superscripts are significantly different (P < 0.021; Fisher’s exact test)
x,yPercent of flea- free homes in a row with unlike letter superscripts are significantly different from day 0 (P < 0.046; Fisher’s exact test)