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. 2018 Jul 16;18:217. doi: 10.1186/s12906-018-2223-8

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Effects of histamine on (a) cells viability and (b) IL-6 production in HaCaT cells. Cells were tested in the presence or absence of histamine. Cells were seeded for 24 h before inducing with different concentrations of histamine (0.1-100 μM). Cells were then further incubated for 0-48 h. C1; uninduced cells in DMEM only. C2; uninduced cells with 0.1% DMSO was set as negative control. All values are the mean ± S.E.M. of three independent experiments. Values of **P < 0.01 and ***P < 0.001 were considered significantly different to uninduced control group (C2)