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. 2018 Jul 16;37:153. doi: 10.1186/s13046-018-0810-7

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 8 — Working model of SAHA and Veliparib co-treatment. SAHA and veliparib exhibited synergistic anticancer efficacy in prostate cancer cells by two mechanisms: synergistically inducing DNA damage, and impairing DNA damage repair by reducing HR DNA repair molecule BRCA1 levels via UHRF1. Co-treatment promoted DNA damage and impaired the damaged DNA repair, and enhanced cell apoptosis and cell death