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. 2018 Jul 16;15:31. doi: 10.1186/s12989-018-0267-z

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Correlation of nanoparticle distribution and local PI overexpression. Cryo-section 3 d post instillation of SiO₂-FITC NPs. a Fluorescence overview image visualizing the principal distribution of NPs mainly located in alveolar macrophages. b MALDI-MS ion image of PI (34:1) ([M-H]⁻) in a parallel tissue section (bordered by a dashed line). The fine dotted lines demarcate seven main areas of PI overexpression. These areas were transferred to the fluorescence image in (a) to show the co-localization with FITC fluorescence. Large blood vessels and bronchioli show strong autofluorescence, but no PI signal