Table 1.

Schedule of Events

Visit Name	Baseline	Month 12	Year 3	Annual Review	Interim Review
Inclusion and Exclusion Criteria	•
Medical History, Physical Exam	•	•	•	•
Vital (BP, Heart rate etc.,) Signs	•	•	•	•
DNA Sample Collection for APOE	•
Neuropsychological assessment		•	•	•
Activities of Daily Living (FAQ)		•	•	•
Plasma and Serum Biomarker Collection	•	•	•	•
Concomitant Medications	•	•	•	•	•
Adverse Events	•	•	•	•	•
3 T MRI Imaging (100%)	•	•	•
CSF Collection by Lumbar Puncture	•