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The effects of SR1078 on NC/Nga conventional mice. (A) Macroscopic view and atopic dermatitis scores, (B) plasma IL-4, (C) plasma histamine, and (D) the RNA expression of Bmal1, Clock, and Per2 in the skin. –AD: SPF NC/Nga mice, +AD: conventional NC/Nga mouse. The values are presented as the mean ± standard deviation, derived from 6 animals.*, P<0.05.
