Table 1.
Candidate target genes for differentially expressed microRNA (miRNA) in PPRV- versus mock-infected goat PBMC
| miRNA name | Up down regulation | P value | Target gene |
|---|---|---|---|
| chi-miR-1 | DOWN | 0 | TLR4, CD84, LOC108635363, LOC102182927, JKAMP, TNFRSF9, IL4R, TAL1, BMF, TRAF3, IFNGR1, IL2RG, TRAF5, HSPA13, IGSF10 |
| chi-miR-143-3p | DOWN | 1.86E−290 | NECTIN4, IKBKG, IL4R |
| chi-miR-323a-3p | UP | 6.59E−241 | IRF3 |
| chi-miR-485-5p | UP | 1.06E−45 | NECTIN4, LOC102182927, CSF2RB |
| chi-miR-1291 | UP | 6.33E−259 | TMEM173, IFNAR1, TRADD, TCP11L1, CDON |
| novel_mir3 | DOWN | 0 | SLAMF6, TMEM173, CCAR2, NECTIN4, PBX1, LOC108637844, IL17B, TRIL, GDF2, NFATC3, CD6, LOC106503960, BCL11A, LOC108635335, APAF1, IFRD1, ISLR2, TLR4, IL1RAP, HSPA2, IRF2BPL, NFKB2, IRAK1 |
| novel_mir85 | UP | 0 | IL1RAP, STAM2, TNFSF13B, TLR9 |
| novel_mir218 | DOWN | 9.37E−14 | IL23A, TAL2, INSIG1, CD82, SLAM |
| chi-miR-150 | UP | 0 | LOC102172159, SLC13A4, IGFLR1, TLR6, RTP1, ITGB1 |
| novel_mir70 | UP | 0 | TLR4, JAM2, IL1RAP, HSPA2, MTOR, ITGAV, STAM2, TNFSF13B, TLR9 |
| chi-miR-30b-3p | DOWN | 4.26E−48 | SRP19, IL22RA1, SOCS5, LOC102170232, LOC102178826, TMEM173, AREL1, IL18BP, IGF2BP3 |
| novel_mir330 | DOWN | 1.09E−10 | PBXIP1, SOCS2, ACKR1, TNIK, CD244, NCR1, LOC102182927, CASP8, ATG9A, TNIK |
| chi-miR-671-5p | UP | 8.28E−63 | CADM2, APAF1, TMEM173, IGF2 |
| chi-miR-182 | UP | 8.31E−304 | IL10, TNFRSF18, BCL11B, LOC106503930, BAX |
| chi-miR-155-3p | UP | 4.01E−197 | PBXIP1, NFKBIA |