Fig. 2.

Modified Spigelman stage and gastric polyp number relative to APC mutation location Patients were divided into 5 groups based on the location of the APC mutation: Attenuated polyposis (n = 71), patients with mutations consistent with attenuated FAP (5′ to c.532, exon 9 alternative splice site c.936-c.1236, intron 9 and 3′ to c. 4785). Intermediate polyposis (n = 42); Profuse polyposis (n = 17) patients with mutations consistent with profuse colonic polyposis (c.3750-c.4392); Deletion of multiple APC exons (n = 6) and deletion of promoter 1B (n = 5). Figure shows percent and number of patients in each APC mutation group by (Panel a) modified Spigelman stage of duodenal polyposis or (Panel b) gastric polyp number. Gastric polyps were estimated as described in methods and set at a maximum of 100