Table 1.
Comparisons of hemodynamic changes during ischemia and reperfusion among different rat groups
| Groups | Baselines | Ischemia | Reperfusion | |||||
|---|---|---|---|---|---|---|---|---|
| 1 min | 5 min | 15 min | 30 min | 30 min | 60 min | 120 min | ||
| HR (beats/min) | ||||||||
| C | 379 ± 18 | 382 ± 14 | 380 ± 19 | 378 ± 15 | 379 ± 16 | 376 ± 16 | 378 ± 14 | 376 ± 19 |
| IRI | 381 ± 12 | 392 ± 11* | 383 ± 13 | 379 ± 18 | 374 ± 18 | 368 ± 12 | 364 ± 12* | 363 ± 12*,† |
| R | 383 ± 13 | 394 ± 12* | 384 ± 15 | 379 ± 13 | 376 ± 13 | 3684 ± 14 | 364 ± 16* | 358 ± 16*,† |
| W | 377 ± 11 | 388 ± 13* | 379 ± 13 | 377 ± 14 | 374 ± 12 | 373 ± 12* | 368 ± 18*,† | 360 ± 16*,† |
| R + IPC | 378 ± 12 | 389 ± 14* | 378 ± 16 | 373 ± 11 | 369 ± 15 | 364 ± 14* | 360 ± 14*,† | 355 ± 16*,† |
| W + IPC | 379 ± 13 | 389 ± 15* | 378 ± 12 | 375 ± 16 | 371 ± 12† | 371 ± 12*,† | 368 ± 12*,† | 366 ± 13* |
| MAP (mmHg) | ||||||||
| C | 118 ± 7 | 117 ± 8 | 116 ± 7 | 117 ± 7 | 116 ± 6 | 116 ± 7 | 115 ± 7 | 115 ± 7 |
| IRI | 117 ± 7 | 106 ± 7* | 115 ± 6 | 109 ± 7 | 112 ± 7 | 106 ± 8 | 104 ± 6* | 96 ± 6*,† |
| R | 116 ± 8 | 105 ± 6* | 114 ± 8 | 105 ± 8 | 103 ± 6* | 101 ± 7 | 96 ± 8* | 91 ± 6*,† |
| W | 114 ± 6 | 106 ± 7* | 115 ± 6 | 113 ± 6 | 110 ± 7 | 108 ± 6†,§ | 105 ± 7*,† | 100 ± 8*,† |
| R + IPC | 116 ± 7 | 108 ± 8* | 116 ± 6 | 110 ± 8 | 98 ± 7* | 95 ± 7* | 93 ± 8*,† | 89 ± 8*,† |
| W + IPC | 115 ± 8 | 108 ± 7* | 115 ± 8 | 113 ± 7 | 111 ± 8 | 109 ± 8‡,§ | 106 ± 7†,§ | 102 ± 7*,‡,§ |
| RPP (1000·min/mmHg) | ||||||||
| C | 43.9 ± 6.4 | 44.5 ± 5.3 | 44.0 ± 3.2 | 43.5 ± 3.4 | 43.1 ± 3.3 | 42.9 ± 3.6 | 42.6 ± 3.2 | 42.7 ± 4.2 |
| IRI | 44.2 ± 4.3 | 40.5 ± 3.0* | 42.9 ± 5.3 | 42.1 ± 3.3 | 41.3 ± 5.5 | 39.8 ± 3.2 | 38.6 ± 5.2* | 37.7 ± 5.2*,† |
| R | 44.6 ± 5.3 | 41.2 ± 5.4* | 44.9 ± 3.4 | 43.6 ± 4.4 | 42.1 ± 3.6 | 41.3 ± 5.3 | 39.9 ± 6.1*,† | 37.9 ± 6.8*,† |
| W | 43.9 ± 6.0 | 40.9 ± 2.9* | 43.7 ± 6.1 | 42.2 ± 2.9 | 40.4 ± 2.9 | 39.4 ± 3.0† | 37.7 ± 2.7*,† | 34.1 ± 2.7*,† |
| R + IPC | 43.8 ± 3.3 | 42.0 ± 3.5 | 44.0 ± 3.1 | 42.2 ± 5.2 | 40.0 ± 3.0 | 39.1 ± 6.1* | 38.6 ± 3.1*,† | 37.8 ± 3.2*,† |
| W + IPC | 44.0 ± 4.0 | 41.0 ± 3.3 | 43.3 ± 3.6 | 43.0 ± 3.7 | 42.9 ± 3.9 | 42.3 ± 3.5† | 42.1 ± 3.2*,†,‡,§ | 41.6 ± 3.2*,†,‡,§ |
Data are presented as mean ± SD, n = 10 in each group. 1 mmHg = 0.133 kPa. IPC: Ischemia preconditioning; C: Control group; IRI: Ischemia/reperfusion injury group; R: Rapamycin group; W: Wortmannin group; R + IPC: Rapamycin + IPC group; W + IPC: Wortmannin + IPC group. Repeated-measures analysis of variance for within-group comparisons. Tukey’s multiple comparison tests for multiple post hoc comparisons. *P<0.05 versus baseline values; †P<0.05 versus C group; ‡P<0.05 versus IRI group; §P<0.05 versus R + IPC group. HR: Heart rate; MAP: Mean arterial pressure; RPP: Rate-pressure product; SD: Standard deviation.