Table 2.
Here we dspict the distribution of genetic, and other subject information within groups of BD-I subjects based on presence or absence of comorbid AUD. AAO refers to age (in years) at onset of first episode. Functional Severity provides a rough estimate of the episode’s clinical impact with results ranging on a scale from 0 to 4 (0 – no symptoms, 1 - no impairment; 2 – impairment in secondary role; 3 – impairment in primary role; 4 – incapacitation). Number of Lifetime Episodes refers to patient report of the total number of respective mood episodes (i.e. mania or depression) in their lifetime.
| Bipolar Disorder Type I | Stats | ||||||
|---|---|---|---|---|---|---|---|
| with Co-Morbid AUD | without Co-Morbid AUD | ||||||
| Mean Age (years +/− SD) | 41.5 | +/− 12.0 | 42.4 | +/− 12.5 | T = 0.37, p = 0.72 | ||
| Sex | F (n = 31) | M (n = 13) | F (n = 25) | M (n = 19) | Χ2 = 1.77, p = 0.18 | ||
| Body Mass Index (+/− SD) | 28.8 +/− 7.9 | 26.7 +/− 4.4 | T = 0.86, p = 0.40 | ||||
| TSPO variant | AA/AG (n = 22) | GG (n = 22) | AA/AG (n = 25) | GG (n = 19) | Χ2 = 0.41, p = 0.52 | ||
| HAM-D | 7.4 +/− 6.8 | 7.5 +/− 7.7 | U = 0.29, p = 0.77 | ||||
| YMRS | 2.6 +/− 3.9 | 2.1 +/− 2.4 | U = −0.08, p = 0.94 | ||||
| Manic Episodes | AAO (years) | 20.5 +/− 12.4 | 25.6 +/− 11.8 | U = −1.88, p = 0.06 | |||
| Functional Severity | 3.9 | 3.6 | U = 1.03, p = 0.30 | ||||
| Number of Lifetime Episodes | 15.8 | 10.8 | U = 1.22, p = 0.22 | ||||
| Major Depressive Episodes | AAO (years) | 16.1 +/− 10.3 | 19.6 +/− 11.9 | U = −1.48, p = 0.14 | |||
| Functional Severity | 3.1 | 3.3 | U = −0.23, p = 0.82 | ||||
| Number of Lifetime Episodes | 16.4 | 12.3 | U = 0.14, p = 0.88 | ||||