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. 2018 May 8;27(15):2644–2657. doi: 10.1093/hmg/ddy173

Figure 5.

Figure 5.

 Small RNAs differentially expressed in control and FSHD2 cells during muscle differentiation (MT versus MB). (A) Small RNAs differentially expressed in control MT compared to MB and in FSHD2 MT compared to MB identified by the DESeq2 analysis performed on all types of small RNAs (Padj < 0.05) (Supplementary Material, Table S2). (B and C) The Venn diagram and heatmaps show miRNAs differentially expressed in FSHD2 MT compared to MB and control MT compared to MB. Although, 26 miRNAs including major myogenic miRNAs were differentially expressed during muscle differentiation (MT versus MB) in both control and FSHD2 samples, fewer miRNAs showed significant expression changes in FSHD2 samples compared to controls (28 versus 62 miRNAs), suggesting potential defects in the FSHD2 muscle differentiation program. In addition to the known miRNAs, the heatmaps in (C) also included novel miRNAs predicted by miRDeep2. (D and E) The Venn diagram and heatmaps show tRNAs differentially expressed in MT samples compared to MB samples. Similar to miRNAs, fewer tRNAs were differentially expressed during muscle differentiation (MT versus MB) in FSHD2 samples than in controls (6 versus 18 tRNAs).