Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jul 6;11:223. doi: 10.3389/fnmol.2018.00223

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2018 Tian, Kay, Sadybekov, Rao, Katritch and Herring.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Rac1 C18Y expression prevents long-term potentiation (LTP) induction. (A,B) Plots of AMPAR-eEPSC amplitude of untransfected neurons (black) and neurons transfected with Rac1 (green) or Rac1 C18Y (red) normalized to the mean AMPAR-eEPSC amplitude before LTP induction (arrow). Sample AMPAR-eEPSC current traces from control (black) and transfected (green for Rac1, red for Rac1 C18Y) neurons before and after LTP inductions are shown (Scale bars: 20 ms, 20 pA). The bar graph shows individual LTP magnitude (mean ± SEM), Wilcoxon Signed Rank Test. Wilcoxon Rank Sum Test was used to compare across independent conditions (i.e., GFP and Rac1 C18Y in (B), *P < 0.05). (A) Wild-type Rac1 expression in CA1 pyramidal neurons does not significantly affect LTP induction (control: n = 7 neurons; Rac1: n = 6 neurons). (B) Rac1 C18Y prevents LTP induction (control: n = 8 neurons; Rac1 C18Y: n = 6 neurons).