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. 2018 Jul 13;11:4019–4028. doi: 10.2147/OTT.S161200

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© 2018 Deng et al. This work is published and licensed by Dove Medical Press Limited

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ECRG4 expression was associated with DNA methylation and could be enhanced by 5-aza-2′-deoxycytidine (5-Aza-dC). (A) DNA methylation of ECRG4 in cell lines. ECRG4 was partially methylated in GES1 but highly methylated in MKN-45, BGC-823, AGS, and SGC-7901 cells; (B) DNA methylation of ECRG4 in six pairs of gastric cancer (GC) tissues and adjacent non-tumor tissues (N = non-malignant gastric tissues; T = primary gastric tissues); (C) ECRG4 mRNA expression was enhanced with increasing concentrations of 5-Aza-dC; (D) ECRG4 protein expression was enhanced with increasing concentrations of 5-Aza-dC. *p<0.05; **p<0.01.