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Verification and validation. (A) Conservation of mass for verification: < 10−12 change with currents from 1, 000 neurons in tissue with heterogeneous diffusion. (B) rxd simulation of 1mA/cm2 constant K+ flux from a traced rat hippocampal CA1 pyramidal neuron and Dirichlet boundary conditions, concentrations at 1 s (averaged over depth). (C) Comparable solution using FiPy with identical current fluxes. (D) Difference between rxd and FiPy concentrations results (note scale in nM).
