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. 2018 Jun 1;32(11-12):836–848. doi: 10.1101/gad.311688.118

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© 2018 Zhao et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 5. — Cartoon illustrating PAPAS-dependent repression of rDNA transcription in response to heat shock. Thermal stress induces transcription of PAPAS and dephosphorylation of CHD4. Hypophosphorylation facilitates binding of CHD4/NuRD to an unstructured A-rich region of PAPAS that covers the rDNA promoter. PAPAS is tethered to the adjacent rDNA enhancer via DNA–RNA triplex formation, thereby targeting CHD4/NuRD to rDNA, where it shifts the promoter-bound nucleosome into a position that does not allow transcription initiation.