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The effect of DR-related gene knockdown on NAC-induced longevity. (A) Knockdown of skn-1, encoding a transcription factor required for DR-induced longevity, has no effect on the lifespan extension induced by NAC supplementation (p > 0.05). (B) The lifespan-extending effect of NAC is completely abolished by RNAi of the daf-16 gene, which is one of the downstream targets of DR response in C. elegans (p < 0.05)
