Table 1. K i values (nM) of OT and peptide analogues for human OTR and vasopressin receptors.
Peptide | OTR | V1a | V1b | V2 |
OTc | 1.2 ± 0.3 | 20 ± 3 | >6000 | >6000 |
dOTc | 1.6 ± 1.3 | 388 ± 157 | nd | >6000 |
dOToc | 1.2 ± 0.9 | 362 ± 124 | nd | >6000 |
dLVTc | 3.4 ± 1.0 | 24 ± 5 | nd | 4844 ± 1670 |
dLVToc | 6.3 ± 3.6 | 31 ± 9 | nd | 5819 ± 1704 |
AlF-NODA-dLVTc | 2.6 ± 1.7 | 157 ± 26 | >6000 | >6000 |
AlF-NODA-dLVToc | 3.3 ± 1.5 | 821 ± 217 | nd | >6000 |