Schematic representation of the experiments in T1DM animal model. (A) Experiment I; after 1 week of adaptation, male ICR mice were injected 5 times with STZ (40 mg/kg/day). Experimental supplement was orally administrated to mice in each group once a day for 22 days after the last injection of STZ. STZ, streptozotocin; MBE, mulberry branch EtOH extract, (B) experiment II; After 1 week of adaptation, male ICR mice were injected 5 times with STZ (40 mg/kg/day). Experimental supplement was orally administrated to mice in each group once a day for 22 days after the last injection of STZ. STZ streptozotocin, ORT oxyresveratrol, Met metformin