Table 3.
Antagonism and synergism in the combined effects of ZEA + OTA and ZEA + α-ZOL, compared with individual toxins
| Binary mixture (μM) | Cell viability (%) | SOD (U/mg.prot) | MDA (nmol/mg.prot) | GSH-Px (U/mg.prot) | GSH (nmol/mg.prot) |
|---|---|---|---|---|---|
| ZEA 30 + OTA 6 | Antagonism | Antagonism | Antagonism | Antagonism | Antagonism |
| ZEA 30 + OTA 12 | Antagonism | Antagonism | Antagonism | Antagonism | Antagonism |
| ZEA 60 + OTA 6 | Antagonism | Antagonisnm | Antagonism | Antagonism | Antagonism |
| ZEA 60 + OTA 12 | Antagonism | Antagonism | Antagonism | Antagonism | Antagonism |
| ZEA 30 + α-ZOL 15 | Antagonism | Antagonism | Antagonism | Antagonism | Antagonism |
| ZEA 30 + α-ZOL 30 | Antagonism | Antagonism | Antagonism | Antagonism | Antagonism |
| ZEA 60 + α-ZOL 15 | Synergism | Synergism | Synergism | Synergism | Synergism |
| ZEA 60 + α-ZOL 30 | Synergism | Synergism | Synergism | Synergism | Synergism |
ZEA zearalenone, OTA ochratoxin A, α-ZOL α-zearalenol, SOD superoxide dismutase, MDA malondialdehyde, GSH-Px glutathione peroxidase, GSH glutathione