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. Author manuscript; available in PMC: 2018 Jul 17.
Published in final edited form as: Sci Transl Med. 2015 Jun 24;7(293):293ra103. doi: 10.1126/scitranslmed.aab2009

Fig. 3. Vitamin B12 biosynthesis genes were down-regulated in the skin microbiota of acne patients compared to healthy individuals.

Fig. 3.

Down-regulation of the genes in P. acnes vitamin B12 biosynthesis pathway was validated in a separate cohort of acne patients (n=9) and healthy individuals (n=15). Consistent with the RNA-Seq data, cysG+cbiX and cbiL were significantly down-regulated, and btuR showed a lower average expression level in acne patients compared to healthy individuals. Significance was determined by Student’s t-test. The mean of the expression levels of each gene is indicated by a black bar. The gene expression data are listed in table S4.