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. Author manuscript; available in PMC: 2018 Jul 17.
Published in final edited form as: Sci Transl Med. 2015 Jun 24;7(293):293ra103. doi: 10.1126/scitranslmed.aab2009

Fig. 5. Vitamin B12 supplementation in the host altered the transcriptome of P. acnes in the skin microbiota.

Fig. 5.

(A) The differentially expressed P. acnes OGUs between the Day0 samples and Day14 samples from the healthy subjects supplemented with vitamin B12. The red and green colors represent the fold change of the OGUs. Red indicates up-regulation after vitamin B12 supplementation and green indicates down-regulation. The functional categories of the OGUs are labeled by the color bars next to the OGUs’ names.

(B) The P. acnes gene expression profile of subject HL414 on day 14 after vitamin B12 supplementation (HL414-Day14) was similar to those from the acne patients and clustered together. The Day0 sample from subject HL414 (“HL414_Day0”, healthy skin, before vitamin B12 supplementation) was similar to the samples from other healthy subjects. Samples from the acne patients were labeled in red (“Acne”), and samples from the healthy subjects were labeled in green (“Healthy”, “Day0”, “Day14”), except for HL414-Day14.